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IDH1 Mouse anti-Human, Clone: IDH1/1152, Abnova™

Mouse monoclonal antibody raised against partial recombinant human IDH1.

Manufacturer:  Abnova Corporation MAB13317

Catalog No. 89-934-338


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Description

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq]

Specifications

Specifications

IDH1
IDH1/1152
Mouse monoclonal antibody raised against partial recombinant human IDH1.
In 1mM PBS (0.05% BSA, 0.05% sodium azide).
IDCD/IDH/IDP/IDPC/PICD
Mouse
IgG1, kappa
100 ug
Store at 4°C.
Monoclonal
Human
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Unconjugated
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be dete
Liquid
IDH1
Recombinant protein corresponding to 119 residues around amino acids 280-420 of human IDH1.
Protein A/G purification
RUO
Primary
3417
SDS
Documents
Product Certifications
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