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IDH1 Mouse anti-Human, Mouse, Rat, Clone: GT1521, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527759

Catalog No. PIMA527759


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Description

Description

Positive Control: 293T, A431, HeLa, HepG2, Huh-7, PC-12, Rat2, Neuro2A, GL261, C8D30, NIH-3T3, Raw264.7, C2C12 Predicted Reactivity: Zebrafish (85%), Xenopus laevis (88%), Sheep (95%), Rhesus Monkey (100%), Bovine (95%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

IDH1 is a member of the isocitrate deydrogenase family, which catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
Specifications

Specifications

IDH1
Monoclonal
1 mg/ml
PBS with no preservative
O75874, O88844, P41562
PICD, IDH, IDP, IDCD, isocitrate dehydrogenase 1 (NADP+), soluble, IDPC
Mouse
IgG2b
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
15926, 24479, 3417
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
GT1521
Unconjugated
IDH1
Liquid
IDH1
Recombit protein encompassing a sequence within the center region of human IDH1. The exact sequence is proprietary.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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