IDH1 Mouse anti-Human, Mouse, Rat, Clone: GT1521, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527759
Positive Control: 293T, A431, HeLa, HepG2, Huh-7, PC-12, Rat2, Neuro2A, GL261, C8D30, NIH-3T3, Raw264.7, C2C12 Predicted Reactivity: Zebrafish (85%), Xenopus laevis (88%), Sheep (95%), Rhesus Monkey (100%), Bovine (95%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.IDH1 is a member of the isocitrate deydrogenase family, which catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
|PBS with no preservative|
|O75874, O88844, P41562|
|PICD, IDH, IDP, IDCD, isocitrate dehydrogenase 1 (NADP+), soluble, IDPC|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|15926, 24479, 3417|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|Recombit protein encompassing a sequence within the center region of human IDH1. The exact sequence is proprietary.|
|Human, Mouse, Rat|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok