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IDH1 Mouse anti-Human, Zebrafish, Clone: 4A3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524877

Catalog No. PIMA524877


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Description

Description

IDH1 is a member of the isocitrate deydrogenase family, which catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
Specifications

Specifications

IDH1
Monoclonal
Unconjugated
IDH1
Liquid
IDH1
Recombit protein corresponding to a region of IDH1.
Protein A
RUO
Antibody
Monoclonal
Human, Zebrafish
Immunohistochemistry (Paraffin), Western Blot
4A3
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
O75874
Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; Cytosolic NADP-isocitrate dehydrogenase; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; IDH1; PICD
Mouse
IgG1
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100006589, 3417
Documents
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