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IDO1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA5107329

Catalog No. PIPA5107329


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Description

Description

Product is supplied at 1 mL (100 µL/mL). Application Notes: IHC-P-Epitopes are unmasked by heating at 60°C in 10 mM sodium citrate, pH6.0, for 60 minutes.

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregcy, autoimmunity, transplantation, and neoplasia.
Specifications

Specifications

IDO1
Polyclonal
Unconjugated
IDO1
liquid
IDO1
A mixture of three rat IDO peptides: MPHSQISPAEGSRRILEEY (1-19), LFSFPGGDCDKGFFLVSLMVE (155-176), and VKPSKQKPMGGHKSEEPS (359-376) coupled to keyhole limpet hemocyanin
Protein A
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
100 μg/mL
PBS with 0.1% BSA and 0.02% sodium azide
P14902
IDO-1, INDO, indolamine 2,3 dioxygenase, indole 2,3-dioxygenase, Indoleamine 2,3-dioxygenase 1, indoleamine-pyrrole 2,3 dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase
Rabbit
IgG
100 μg
4° C
Primary
3620
Documents
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