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IFIT1 Mouse anti-Human, Clone: OTI3G8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525050

Catalog No. PIMA525050


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Description

Description

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5 ft.-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2 ft.-O-methylation of the 5 ft. cap and bear a 5 ft.-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2 ft.-O-methylase for their mRNAs or by stealing host cap containing the 2 ft.-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
Specifications

Specifications

IFIT1
Monoclonal
1.0 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P09914
C56, G10P1, GARG-16, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, RNM561, Interferon, alpha-inducible protein (MW 56kD), interferon-induced 56 kDa protein, interferon-induced protein 56
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3434
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI3G8
Unconjugated
IFIT1
Liquid
IFIT1
Full length human recombit protein of IFIT1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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