IFIT1 Mouse anti-Human, Clone: OTI3G8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525050
DescriptionInterferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5 ft.-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2 ft.-O-methylation of the 5 ft. cap and bear a 5 ft.-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2 ft.-O-methylase for their mRNAs or by stealing host cap containing the 2 ft.-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|C56, G10P1, GARG-16, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, RNM561, Interferon, alpha-inducible protein (MW 56kD), interferon-induced 56 kDa protein, interferon-induced protein 56|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of IFIT1 produced in HEK293T cell|
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