Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

IFN beta Mouse anti-Human, FITC, Clone: A1 (IFNb), eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen BMS1044FI

Catalog No. 50-112-5239


Add to cart

Description

Description

Description: The IFNb/A1 clone recognizes natural human IFN-beta and recombits beta1a and beta1b. It is capable of neutralizing IFN-beta. Interferon beta is synthesized and secreted by fibroblasts and many other cell types in response to pathogens. IFN-beta binding to type I interferon receptors induces the upregulation of IRF-7 and activation of Rnase L. IRF-7 can exert a positive feedback on IFN-beta production. RNase L cleaves both viral and cellular single stranded mRNA, thereby limiting viral replication and dissemination. Applications Tested: ELISA, Neutralization tests, Western Blotting. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
Specifications

Specifications

IFN beta
Monoclonal
0.1 mg/mL
TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
P01574
IFNB1
IgG1, kappa
100 μg
4° C
Primary
3456
ELISA, Functional Assay, Western Blot
A1 (IFNb)
FITC
IFNB1
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only.