Invitrogen™ IFN omega Monoclonal Antibody (OMG-5), eBioscience™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ BMS1021

Catalog No. 50-176-84

Description

Description: Anti-human IFN-omega (OMG-5) neutralize the antiviral activity of IFN-omega. In the human genome, the IFN-omega gene family consists of seven members located on chromosome 9. However, only one of these genes is functional giving rise to the IFN-omega protein, whereas the others are non-functional pseudogenes. The IFN-omega gene is not expressed in unstimulated cells. Viral infection results in expression of the gene giving rise to the N-glycosylated protein consisting of 172 or 174 amino acids and an apparent molecular mass of about 25kDa. A single carbohydrate group consists mainly of biantennary complex oligosaccharides with variable amounts of N-acetyl neuraminic acid. In quantitative terms, IFN-omega is a major component of human leukocyte IFN; with a contribution to its total antiviral activity estimated to be in the range of 10 -15 %. Applications Tested: ELISA.

IFN-omega is a type I interferon that can be induced by virus-infected leukocytes. Members of the type I interferon family, which includes IFN-alpha, IFN-beta, and IFN-omega, signal through the IFNAR-1/IFNAR-2 receptor complex, and exert antiviral and antiproliferative activities. IFN-omega exhibits about 75% sequence homology with IFN-alpha, and contains two conserved disulfide bonds that are necessary for full biological activity.

Specifications

• Antigen: IFN omega
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.2-7.4
• Gene Accession No.: P05000
• Gene Symbols: IFNW1
• Immunogen: Rec. Human IFN omega.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA
• Clone: OMG-5
• Conjugate: Unconjugated
• Gene: IFNW1
• Gene Alias: IFN o; IFN ?; IFNo; IFNomega; IFN-omega 1, interferon omega-1; IFNW; IFNW1; IFN?; Interferon; Interferon alpha-II-1; Interferon o; Interferon OMEGA; interferon omega 1; interferon omega-1; Interferon ?; interferon, omega 1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3467
• Content And Storage: -20°C
• Form: Liquid