IFNAR1 Rabbit anti-Human, Mouse, Rat, Invitrogen
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Invitrogen MA524850
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
|Human, Mouse, Rat|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.2|
|Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1; IFNAR1; IFNAR; IFNR1; IFN R1; IFN-alpha/betaRalpha;IFN-alpha/betaR1; IFN alpha/betaRalpha; IFNalpha/betaR1; IFNalpha/beta-Ralpha;IFNalpha/beta R1;|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|15975, 288264, 3454|
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