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IGF1R Mouse anti-Human, Clone: OTI11E4, liquid, TrueMAB™
Mouse Monoclonal Antibody
Supplier: OriGene TA807836
SDSDocumentsProduct Certifications Promotions
DescriptionInsulin growth factor 1 receptor belongs to the family of tyrosine receptor kinases. It is involved in activation of various substrates including IGF and neurotensin, regulation of metabolism, cell division, maintece, and inflammation response. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|Human recombit protein fragment corresponding to amino acids 741-935 of human IGF1R produced in Insect.|
|CD221, IGFIR, IGFR, JTK13|
|-20° C, Avoid Freeze/Thaw Cycles|
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