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IGF2R Mouse anti-Human, APC, Clone: MEM-238, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen A15710

Catalog No. 50-113-7070


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Description

Description

CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
Specifications

Specifications

IGF2R
Monoclonal
APC
IGF2R
Liquid
IGF2R
Human CD222
Purified
RUO
Antibody
Monoclonal
Human
Flow Cytometry
MEM-238
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
P11717
CD222, CIMPR, M6P-R, MPR1, MPRI, 300 kDa mannose 6-phosphate receptor, CI Man-6-P receptor, CI-MPR, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R, IGF2R
Mouse
IgG1
100 tests
4° C
Primary
3482
Documents
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