IKK alpha Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA587434

Catalog No. PIPA587434

Description

Positive Samples: Jurkat, HeLa, HepG2; Cellular Location: Cytoplasm, Nucleus

NFkB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death. In the cytoplasm NFk B is negatively modulated by the inhibitory proteins Ik-B. In turn Ik-B is phosphorylated by a cellular kinase complex called IKK. IKK is a heterodimer composed of two kinases: IKK alpha and IKK beta which phosphorylate Ik-B leading to its degradation and the resulting translocation of NFk B to the nucleus. IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF alpha , endotoxins and overexpression of cellular kinases like MEKK1. Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.

Specifications

• Antigen: IKK alpha
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHUK
• Gene Symbols: CHUK
• Immunogen: Recombit protein of human CHUK
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunofluorescence, Western Blot
• Concentration: 7.51 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O15111, Q60680
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1147, 12675
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid