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IL-1 alpha Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA585366

Catalog No. PIPA585366


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Description

Description

Keep as concentrated solution. Positive Control: HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Specifications

Specifications

IL-1 alpha
Polyclonal
Unconjugated
IL1A
IL-1A antibody; IL1 antibody; IL1-ALPHA antibody; IL1F1 antibody; IL1A antibody; pro-interleukin-1-alpha antibody; IL-1 alpha antibody; interleukin-1 alpha antibody; preinterleukin 1 alpha antibody; hematopoietin-1 antibody; interleukin 1; alpha antibody
Rabbit
Antigen Affinity Chromatography
RUO
3552
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.73 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
P01583
IL1A
Recombit protein encompassing a sequence within the center region of human IL1 alpha.
100 μL
Primary
Human
Antibody
IgG
SDS
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