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IL-1 beta/IL-1F2 Rat anti-Mouse, Clone: 30311R, R&D Systems™

Recombinant Monoclonal Antibody

$148.35 - $369.00

Specifications

Antigen IL-1 beta/IL-1F2
Formulation Supplied as a solution in PBS. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Format Purified
Clone 30311R
Applications Immunocytochemistry, Neutralization
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MAB401R100 View Documents R&D Systems
MAB401R100
100 ug Each for $369.00
Add to cart
 
MAB401RSP View Documents R&D Systems
MAB401RSP
25 ug Each for $148.35
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Description

Description

IL-1 is a name that designates two pleiotropic cytokines, IL-1α (IL-1F1) and IL-1β (IL-1F2), which are the products of distinct genes. IL-1α and IL-1β are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1α and IL-1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1α or IL-1β and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1β but functions as a decoy receptor and negative regulator of IL-1β activity. IL-1ra functions as a competitive antagonist by preventing IL-1α and IL-1β from interacting with IL-1 RI (1-4). The mouse IL-1β cDNA encodes a 269 aa precursor. A 117 aa propeptide is cleaved intracellularly by the cysteine protease IL-1β-converting enzyme (Caspase-1/ICE) to generate the active cytokine (5, 6). The 17kDa mature mouse IL-1β shares 90% aa sequence identity with cotton rat and rat and 65-78% identity with canine, equine, feline, human, porcine, and rhesus macaque IL-1β.
Specifications

Specifications

IL-1 beta/IL-1F2
Purified
Immunocytochemistry, Neutralization
Rat
Protein A or G purified from cell culture supernatant
RUO
Supplied as a solution in PBS. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
30311R
Unconjugated
IgG1
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
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