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IL-1 beta Rabbit anti-Mouse, Biotin, Polyclonal, eBioscience™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

$107.00 - $322.00

Specifications

Antigen IL-1 beta
Target Species Mouse
Conjugate Biotin
Isotype IgG
Applications ELISA
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-121-75 Non-distribution product as customer accommodation.
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Invitrogen
13711281
50 μg Each for $107.00
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50-121-76 Non-distribution product as customer accommodation.
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Invitrogen
13711285
500 μg Each for $322.00
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Description

Description

Description: The biotinylated polyclonal rabbit antibody reacts with mouse interleukin-1beta (IL-1beta), a 17 kDa factor secreted primarily by monocytes. IL-1 has effects on T-helper cells, inducing IL-2 secretion and expression of IL-2 receptors. IL-1 has effects on B cells, promoting cell proliferation and immunoglobulin synthesis. Applications Reported: Biotin anti-mouse interleukin-1 beta (IL-1 beta) has been reported for use as the detection antibody for a mouse IL-1 beta ELISA. Applications Tested: The biotinylated polyclonal rabbit anti-mouse IL-1 beta antibody has been tested as the detection antibody in a sandwich ELISA for analysis of mouse IL-1 beta in combination with the unlabelled B122 (14-7012) antibody for capture and recombit mouse IL-1 beta (14-8012) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 1.0 - 6.0 µg/mL. A standard curve consisting of doubling dilutions of the recombit standard over the range of 2000 pg/mL - 15 pg/mL should be included in each ELISA plate. Filtration: 0.2 µm post-manufacturing filtered.

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Specifications

Specifications

IL-1 beta
Biotin
ELISA
Primary
Polyclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO
Mouse
IgG
Polyclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!

For Research Use Only.

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