IL-22 Monoclonal Antibody (IL22JOP), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Supplier:  Invitrogen 46722282

Catalog No. 50-112-9736

Description

Description: The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20 kDa member of the IL-10 cytokine family that is secreted primarily by Th17 cells, NK cells, and other T cells. Compared to IL-6 or TGF beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells. This observation suggests that IL-22 may be secreted by more fully differentiated Th17 cells in vivo. Recently, it was demonstrated that IL-22 could protect hosts from bacterial infection of the lungs and gut. Moreover, it has been reported that anti-CD3/CD28-induced production of IL-22 by PBMCs was elevated significantly in asthma patients compared to control patients. Flow cytometric analysis also showed that the frequencies of IL-17+IL-22+ CD4 T cells were increased in PBMCs from patients with ankylosing spondylitis and rheumatoid arthritis. IL22JOP is published to recognize rhesus IL-22. Applications Reported: This IL22JOP antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This IL22JOP antibody has been tested by intracellular staining and flow cytometric analysis of TH17 polarized mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.

IL-22 Monoclonal antibody specifically detects IL-22 in Human, Mouse, Rhesus Monkey samples. It is validated for Flow Cytometry.

Specifications

• Antigen: IL-22
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q9GZX6, Q9JJY9
• Gene Symbols: IL22
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 50616, 50929, 718047
• Content And Storage: 4° C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: IL22JOP
• Conjugate: PerCP-eFluor 710
• Gene: IL22
• Gene Alias: Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; ILTIF; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18
• Host Species: Rat
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rhesus Monkey
• Product Type: Antibody
• Isotype: IgG2a κ

For Research Use Only.