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IL-31 Mouse anti-Human, PE, Clone: U26-947, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 566326

Catalog No. BDB566326



The U26-947 monoclonal antibody specifically binds to Interleukin-31 (IL-31). IL-31 belongs to the IL-6 family of cytokines. It is primarily produced by activated type-2 helper T cells (Th2 cells) and skin-homing cutaneous lymphocyte-associated antigen (CLA)-positive T cells in individuals with atopic dermatitis. IL-31 binds to a heterodimeric cell surface receptor comprised of an IL-31 Receptor alpha subunit (IL-31Rα) and Oncostatin M Receptor beta subunit (OSMRβ). The IL-31 Receptor complex is variably expressed on epithelial cells, keratinocytes, monocytes, macrophages, or eosinophils. IL-31 signaling through the Jak/STAT pathway may induce the release ofproinflammatory cytokines including IL-1 beta (IL-1β), IL-6, IL-8, CXCL1(GRO1α), and CCL2 (MCP-1). Overexpressed IL-31 may be detected in individuals with allergic asthma, allergic rhinitis, or atopic dermatitis.

R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.


Affinity Purified
Mouse BALB/c IgG2a, κ
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Interleukin-31, Interleukin 31, IL31
Human IL-31 Recombinant Protein
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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