Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

IL-31 Mouse anti-Human, PE, Clone: U26-947, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 566326

Catalog No. BDB566326


Add to cart

Description

Description

The U26-947 monoclonal antibody specifically binds to Interleukin-31 (IL-31). IL-31 belongs to the IL-6 family of cytokines. It is primarily produced by activated type-2 helper T cells (Th2 cells) and skin-homing cutaneous lymphocyte-associated antigen (CLA)-positive T cells in individuals with atopic dermatitis. IL-31 binds to a heterodimeric cell surface receptor comprised of an IL-31 Receptor alpha subunit (IL-31Rα) and Oncostatin M Receptor beta subunit (OSMRβ). The IL-31 Receptor complex is variably expressed on epithelial cells, keratinocytes, monocytes, macrophages, or eosinophils. IL-31 signaling through the Jak/STAT pathway may induce the release ofproinflammatory cytokines including IL-1 beta (IL-1β), IL-6, IL-8, CXCL1(GRO1α), and CCL2 (MCP-1). Overexpressed IL-31 may be detected in individuals with allergic asthma, allergic rhinitis, or atopic dermatitis.

R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.
Specifications

Specifications

IL-31
PE
Affinity Purified
Murine
Mouse BALB/c IgG2a, κ
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
U26-947
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Interleukin-31, Interleukin 31, IL31
Human IL-31 Recombinant Protein
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
RUO
Primary
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit