IL-31 Mouse anti-Human, PE, Clone: U26-947, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 566326
The U26-947 monoclonal antibody specifically binds to Interleukin-31 (IL-31). IL-31 belongs to the IL-6 family of cytokines. It is primarily produced by activated type-2 helper T cells (Th2 cells) and skin-homing cutaneous lymphocyte-associated antigen (CLA)-positive T cells in individuals with atopic dermatitis. IL-31 binds to a heterodimeric cell surface receptor comprised of an IL-31 Receptor alpha subunit (IL-31Rα) and Oncostatin M Receptor beta subunit (OSMRβ). The IL-31 Receptor complex is variably expressed on epithelial cells, keratinocytes, monocytes, macrophages, or eosinophils. IL-31 signaling through the Jak/STAT pathway may induce the release ofproinflammatory cytokines including IL-1 beta (IL-1β), IL-6, IL-8, CXCL1(GRO1α), and CCL2 (MCP-1). Overexpressed IL-31 may be detected in individuals with allergic asthma, allergic rhinitis, or atopic dermatitis.R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.
|Mouse BALB/c IgG2a, κ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Interleukin-31, Interleukin 31, IL31|
|Human IL-31 Recombinant Protein|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok