IL-31RA Rat anti-Human, Alexa Fluor 647, Clone: V1-1110, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 566351

Catalog No. BDB566351

Description

The V1-1110 monoclonal antibody specifically recognizes the Interleukin-31 Receptor subunit alpha (IL-31R alpha, IL-31RA, or IL-31Rα) which is also known as gp130-like Monocyte Receptor (GLMR or hGLM-R) or Cytokine receptor-like 3 (CRL3). IL-31RA is a type I transmembrane glycoprotein that is encoded by IL31RA /and is classified as a type I cytokine receptor. IL-31RA associates with the Oncostatin M Receptor (OSMR) to form a heterodimeric signaling receptor for IL-31. Through this heterodimeric receptor, IL-31 can elicit intracellular JAK/STAT (including activated Stat3, Stat5, or Stat1), RAS/ERK and PI3K/AKT signal transduction pathways. IL-31RA is variably expressed by monocytes, dendritic cells, keratinocytes, and epithelial cells. IL-31RA and OSMR are inducibly expressed by cells within the myelomonocytic lineage such as monocytes treated with IFN-γ andbacterial lipopolysaccharide (LPS). IL-31RA signaling plays important roles in both innate and adaptive immunity and inflammation in tissues that are in close contact with the environment including the skin, lung, and intestines.

Alexa Fluor™ 647 conjugates are highly photostable and remain fluorescent over a broad pH range. The excitation and emission maxima are nearly identical to those of APC. However, APC tends to be brighter while Alexa Fluor™ 647 is more optimal for intracellular applications. This fluorochrome exhibits uncommon photostability, making it an ideal choice for use in fluorescence microscopy. Due to nearly identical excitation and emission properties but different spillover characteristics, APC and Alexa Fluor™ 647 cannot be used simultaneously.

Specifications

• Antigen: IL-31RA
• Clone: V1-1110
• Conjugate: Alexa Fluor 647
• Gene Alias: IL31RA, IL-31R-alpha, GLMR, GLM-R, hGLM-R, CRL3
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2a κ

• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Rat
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.