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IL-33R (ST2) Rat anti-Mouse, Brilliant Violet 421, Clone: U29-93, BD

Rat Monoclonal Antibody

$175.00 - $365.00

Specifications

Antigen IL-33R (ST2)
Clone U29-93
Immunogen Mouse IL-33R Recombinant Protein
Host Species Rat
Isotype Rat IgG2a, κ
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB566310 View Documents BD Biosciences
566310
25μg Each for $175.00
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BDB566309 View Documents BD Biosciences
566309
100μg Each for $365.00
Add to cart
 
Description

Description

The U29-93 monoclonal antibody specifically binds to the mouse Interleukin-33 Receptor (IL-33 Receptor, or IL-33R) which is also known as ST2. The IL-33R exists in either a type I transmembrane or soluble glycoprotein form. These IL-33R forms are encoded by the Il1rl1 (Interleukin-1 receptor-like 1) gene which belongs to the IL-1 Receptor family within the Ig superfamily. The IL-33R is expressed by subsets of T cells, including Th2-like cells and some regulatory T cells, as well as some innate lymphocytes, eosinophils, basophils, and mast cells. The IL-33R (also known as the IL-33R alpha subunit, or binds IL-33 and complexes with the IL-1R Accessory Protein (IL1RAP) to form a functional signaling receptor complex that can induce the production of T helper type 2 (Th2) cytokines. The soluble IL-33R may function as a decoy receptor which can block the binding of IL-33 to the transmembrane IL-33R. The IL-33R plays roles in inflammation, immunity, and allergy.

The antibody was conjugated to BD Horizon BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407nm and Em Max at 421nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates. BV421 is a polymer-based dye excited by the violet laser and is one of the brightest fluorochromes offered by BD Biosciences. Conjugates are typically 10 times brighter than Pacific Blue™ conjugates and are often as bright as or brighter than PE conjugates. Due to nearly identical excitation and emission properties but different spillover characteristics, BD Horizon BV421, Pacific Blue™, and BD Horizon™ V450 cannot be used simultaneously.
Specifications

Specifications

IL-33R (ST2)
Mouse IL-33R Recombinant Protein
Rat IgG2a, κ
Affinity Purified
Monoclonal
Il1rl1, ST2, ST2L, IL-33R alpha, IL-33Rα, IL33RA, Ly84, DER4, Fit-1
RUO
U29-93
Rat
Brilliant Violet 421
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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