IL-37 Mouse anti-Human, Biotin, Clone: 37D12, eBioscience
Mouse Monoclonal Antibody
Manufacturer: Invitrogen 13737982
Description: This 37D12 monoclonal antibody reacts with human IL-37. IL-37 is a member of the interleukin 1 cytokine family and is also known as IL-1F7 and IL-1H4. IL-37 suppresses innate inflammatory and immune responses and exhibits anti-inflammatory characteristics resembling those of IL-1R8. IL-37 binds to the alpha chain of IL-18R with low affinity and does not recruit the essential signaling co-receptor IL-18 beta or mediate pro-inflammatory activity. IL-37 also binds to IL-18 binding protein (IL-18BP) and enhances the antagonistic effects of IL-18BP. IL-37 forms a trimeric complex with IL-18BP and IL-18R beta, which results in the blockade of IL-18 activity. Transcripts of IL-37 have been detected in human tissues, such as lung, testis, and colon tumors, as well as some human cell lines. Applications Reported: This 37D12 antibody has been reported for use in immunocytochemistry followed by cytospin. Applications Tested: This 37D12 antibody has been tested by immunocytochemistry of fixed and permeabilized normal human peripheral blood mononuclear cells and can be used at less than or equal to 20 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 µm post-manufacturing filtered.The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1, FIL1 zeta, IL-1 zeta, IL-1F7b (IL-1H4, IL-1H, IL-1RP1), IL-1X protein, IL1F7 (canonical product IL-1F7b), interleukin 1 family member 7, interleukin 1, zeta, interleukin-1 homolog 4, interleukin-1 superfamily z, interleukin-1-related protein, interleukin-23, interle|
|4° C, store in dark, DO NOT FREEZE!|
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