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IL-5 Polyclonal Antibody, Invitrogen™

Goat Polyclonal Antibody

Supplier:  Thermo Scientific PA124791

Catalog No. PIPA124791

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

PA1-24791 detects IL5 from human and mouse samples. PA1-24791 has been successfully used in neutralization, inhibition assays, and Western blot procedures. Anti-Human IL5 was tested for its ability to neutralize the biological activity of recombit, human IL5 on human TF-1 cells, adapted to grow with IL5 stimulation. The PA1-24791 immunogen is recombit human IL5, expressed in Sf21 insect cells. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IL-5
Polyclonal
Unconjugated
P05113, P04401
IL5
Recombit human IL5, expressed in Sf21 insect cells.
250 μg
Primary
Human, Mouse
Antibody
IgG
ELISA, Inhibition Assays, Neutralization, Western Blot
1 mg/mL
IL5
Interleukin-5, EDF, IL-5, TRF, T-cell replacing factor, TRF, Eosinophil differentiation factor, B cell differentiation factor I
Goat
Protein G
RUO
16191, 3567
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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