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IL-6 Mouse anti-Human, Clone: 1936R, R&D Systems™

Recombinant Monoclonal Antibody

$148.35 - $369.00

Specifications

Antigen IL-6
Formulation Supplied as a solution in PBS. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Format Purified
Clone 1936R
Applications Flow Cytometry, Immunocytochemistry, Neutralization
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MAB2061R100 View Documents R&D Systems
MAB2061R100
100 ug Each for $369.00
Add to cart
 
MAB2061RSP View Documents R&D Systems
MAB2061RSP
25 ug Each for $148.35
Add to cart
 
Description

Description

Interleukin 6 (IL-6) is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22-28kDa phosphorylated and variably glycosylated molecule (1-4). Mature human IL-6 is 183 amino acids (aa) in length and shares 41% aa sequence identity with mouse and rat IL-6 (5). Alternate splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties (6-9). Human IL-6 is equally active on mouse and rat cells (10). IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R, triggering IL-6 R association with gp130 and gp130 dimerization (11). gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM (12). Soluble forms of IL-6 R are generated by both alternate splicing and proteolytic cleavage (3). In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R elicit responses from gp130-expressing cells that lack cell surface IL-6 R (3). Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R is predominantly restricted to hepatocytes, leukocytes, and lymphocytes (3). Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R but not from other cytokines that utilize gp130 as a coreceptor (4, 13).
Specifications

Specifications

IL-6
Purified
Flow Cytometry, Immunocytochemistry, Neutralization
Mouse
Protein A or G purified from cell culture supernatant
RUO
Supplied as a solution in PBS. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
1936R
Unconjugated
IgG2b
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
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