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IL-6 Rat anti-Mouse, Biotin, Clone: MP5-32C11, eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

$108.00 - $280.00

Specifications

Antigen IL-6
Clone MP5-32C11
Target Species Mouse
Conjugate Biotin
Isotype IgG2a, kappa
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-121-63 Non-distribution product as customer accommodation.
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Invitrogen
13706281
50 μg Each for $108.00
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50-121-64 Non-distribution product as customer accommodation.
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Invitrogen
13706285
500 μg Each for $280.00
Add to cart
 
Description

Description

Description: The MP5-32C11 antibody reacts with mouse interleukin-6 (IL-6), a 21-28 kDa cytokine secreted by a variety of cell types. Applications Reported: MP5-32C11 has been reported for use in detection of mouse IL-6 by ELISA and ELISPOT. Applications Tested: The MP5-32C11 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of mouse Interleukin-6 (IL-6) in combination with the purified MP5-20F3 (14-7061) antibody for capture and recombit mouse IL-6 (14-8061) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 µg/mL. A standard curve consisting of doubling dilutions of the recombit standard over the range of 1000 pg/mL - 8 pg/mL should be included in each ELISA plate. Filtration: 0.2 µm post-manufacturing filtered.

Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.
Specifications

Specifications

IL-6
Mouse
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C, do not freeze
MP5-32C11
Biotin
ELISA
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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