IL12B Mouse anti-Human, Clone: C8.6, Abnova™
Mouse monoclonal antibody raised against human IL12B.
Manufacturer: Abnova Corporation MAB12705
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq]
|Mouse monoclonal antibody raised against human IL12B.|
|In PBS, 150mM NaCl, pH 7.2 (0.09% sodium azide).|
|Store at 4°C.
Aliquot to avoid repeated freezing and thawing.
|Flow Cytometry, Immunohistochemistry (PFA fixed), Western Blot|
|Flow Cytometry Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20-40 ug/mL) Western Blot The optimal working dilution should be determined by the end user.|
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