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IL12RB1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Thermo Scientific PA597865

Catalog No. PIPA597865


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Description

Description

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Specifications

Specifications

IL12RB1
Polyclonal
Unconjugated
IL12RB1
Liquid
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3594
ELISA, Western Blot
3.5 mg/mL
PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
P42701
IL12RB1
Recombit Human Interleukin-12 receptor subunit beta-1 protein (119-280AA)
Protein G
RUO
Antibody
Polyclonal
Human
Documents
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