IL12RB2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA550685
The antibody detects endogenous levels of total IL12RB2 protein.The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn ft.s disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
|Synthetic peptide corresponding to a region derived from internal residues of human interleukin 12 receptor, beta 2|
|Antigen affinity chromatography|
|PBS with 50% glycerol and 0.05% sodium azide; pH 7.3|
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