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IL12RB2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550685

Catalog No. PA550685


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Description

Description

The antibody detects endogenous levels of total IL12RB2 protein.

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn ft.s disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Specifications

Specifications

IL12RB2
Polyclonal
Unconjugated
IL12RB2
Liquid
IL12RB2
Synthetic peptide corresponding to a region derived from internal residues of human interleukin 12 receptor, beta 2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
2.7 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q99665
RP11-102M16.1
Rabbit
IgG
100 μL
-20°C
Primary
3595
Documents
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