IL17RB Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA587674

Catalog No. PIPA587674

Description

Immunogen sequence: REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMN VSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIG AHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRY MALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVP FPLDNNKSKP GGWLP; Positive Samples: HepG2, 293T, SW620, A-549, B-cell, Mouse liver, Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane protein

Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain.

Specifications

• Antigen: IL17RB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IL17RB
• Gene Alias: CRL4, cytokine receptor CRL4, cytokine receptor-like 4, ecotropic viral integration site 27, EVI27, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B, IL-17B receptor, IL17BR, IL-17ER, Il17rb, IL-17RB, IL17RH1, IL-17Rh1, IL-20, interleukin 17 receptor B, interleukin 17 receptor homolog 1, interleukin 17B receptor, interleukin-17 receptor B, Interleukin-17B receptor, MGC138900, MGC138901, MGC5245, UNQ2501/PRO19612, ZCYTO7
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 306247, 50905, 55540
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene Accession No.: Q9JIP3, Q9NRM6
• Gene Symbols: IL17RB
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 18-292 of human IL17RB (NP_0611952)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG