IL23R Mouse anti-Human, Clone: OTI5C4, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF807388
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOIL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
|Human recombit protein fragment corresponding to amino acids 57-355 of human IL23R produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|interleukin 23 receptor|
|-20° C, Avoid Freeze/Thaw Cycles|
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