IL23R Mouse anti-Human, Clone: OTI5H9, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF807494

Catalog No. 50-166-8298

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.

Specifications

• Antigen: IL23R
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: IL23R
• Gene Alias: interleukin 23 receptor
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 149233
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI5H9
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q5VWK5
• Gene Symbols: IL23R
• Immunogen: Human recombit protein fragment corresponding to amino acids 57-355 of human IL23R produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1