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IL23R Mouse anti-Human, Mouse, Non-human primate, Clone: 15N6C6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524804

Catalog No. PIMA524804


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Description

Description

IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
Specifications

Specifications

IL23R
Monoclonal
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide; pH 7.4
Q5VWK5, Q8K4B4
IBD17, IL-23 receptor, IL-23R, interleukin 23 receptor, interleukin-23 receptor
Mouse
IgG1, kappa
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
149233, 209590
Immunohistochemistry (Paraffin), Western Blot
15N6C6
Unconjugated
IL23R
Liquid
IL23R
Synthetic peptide corresponding to amino acids 288-315 of Human IL-23 receptor.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Non-human primate
Documents
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