IL23R Mouse anti-Human, Mouse, Non-human primate, Clone: 15N6C6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524804
DescriptionIL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
|PBS with 0.05% BSA and 0.05% sodium azide; pH 7.4|
|IBD17, IL-23 receptor, IL-23R, interleukin 23 receptor, interleukin-23 receptor|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunohistochemistry (Paraffin), Western Blot|
|Synthetic peptide corresponding to amino acids 288-315 of Human IL-23 receptor.|
|Human, Mouse, Non-human primate|
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