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IL36 gamma Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 247231AP

Catalog No. 50-173-4507


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Description

Description

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.
Specifications

Specifications

IL36 gamma
0.49 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9NZH8
IL 1 epsilon, IL 1 related protein 2, IL 1F9, IL 1H1, IL 1RP2, IL1E, IL1F9, IL-1F9, IL1H1, IL1RP2, IL-36 gamma, IL-36gamma, Interleukin 1 epsilon, Interleukin 1 family member 9, interleukin 1 family, member 9, Interleukin 1 homolog 1
Rabbit
IgG
150 μL
-20°C
Primary
56300
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
IL36G
Liquid
IL36G
IL36 gamma Fusion Protein Ag21489
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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