Quantify specific IgE antibodies with ImmunoCAP Tree Allergen Components down to the molecular level, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen at the molecular level. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show, in general, a higher correlation with an allergic disease.
ImmunoCAP Specific IgE offers the laboratory:
Truly quantitative measuring range from 0.1-100 kUA/L
Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
Excellent consistency over time, and between countries, systems, labs and persons measuring range from 0.1-100 kUA/L
Expected test values
ImmunoCAP Specific IgE Allergen Component results are reported as quantitative values in the range 0.1 to 100 kUA/L, where A represents allergen-specific antibodies. ImmunoCAP Allergen Components are purified proteins, either natural or recombinant. ImmunoCAP Allergen Component tests for specific IgE antibodies employ these purified, individual allergen proteins, to identify and quantify the levels of IgE antibodies at the molecular level. These assays offer the unique opportunity to assess a person’s allergic sensitization pattern at the protein level. IgE antibodies to different protein families often elicit different types of reactions, so testing to identify which proteins are inducing the IgE response may indicate if a patient’s prior symptoms, or positive test results, were caused by allergy to a given substance or by a cross-reaction with another allergen. Component testing also helps the clinician weigh a patient’s risk of a systemic reaction versus a more mild or localized response.
Specimen collection and preparation
Serum and plasma (EDTA or heparin) samples from venous or capillary blood can be used
Collect blood samples using standard procedures
Keep specimens at room temperature (RT) for shipping purposes only
Store at 2-8°C up to one week, otherwise store at -20°C
Avoid repeated freezing and thawing
Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.
The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.
Knowing IgE antibody levels provides guidance to clinicians to:
Identify offending allergens
Tailor advice to individual patients
Indicate development of tolerance (food allergy, specific immunotherapy)
Inform optimized individual medical treatment plans
Refer to specialists appropriately
Evaluate whether or not specific immunotherapy is an option
Specific IgE testing also aids in the identification of patients at risk of:
The allergy marcha progression of skin symptoms to respiratory symptoms
Severe symptoms including asthma exacerbationsa progression of mild symptoms to severe symptoms
Progression of recurrent symptoms to persistent symptoms
As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.
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