Importin 8 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA589979
Immunogen sequence: TRQLVNREDR SKAEKADMEE NEEISSDEEE TNVTAQAMQS NNGRGEDEEE EDDDWDEEVL EETALEGFST PLDLDNSVDE YQFFTQALIT VQSRDAAWYQ LLMAPLSEDQ RTALQEVYTL AEHRRTVAEA KKKIEQQGGF TFENKGVLSA FNFGTVPSNN; Positive Samples: HeLa, Jurkat, Mouse brain, Rat testis; Cellular Location: Cytoplasm, NucleusImportin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.
|Recombit fusion protein containing a sequence corresponding to amino acids 878-1037 of human IPO8|
|Human, Mouse, Rat|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Antigen Affinity Chromatography|
|-20° C, Avoid Freeze/Thaw Cycles|
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