Importin 8 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA141599

Catalog No. 01-675-216

Description

Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.

Specifications

• Antigen: Importin 8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IPO8
• Gene Alias: 6230418K12Rik; Abcc10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; C130009K11Rik; FLJ26580; imp8; importin 8; importin-8; IPO8; MRP7; Om1; OM-1; oocyte maturation 1; RAN binding protein 8; ran-binding protein 8; RANBP8
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 10526
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
• Concentration: 1.0 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: O15397
• Gene Symbols: IPO8
• Immunogen: Synthetic peptide corresponding to residues 850-900 of human Importin-8.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Non-human Primate
• Product Type: Antibody
• Isotype: IgG