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Edvotek™ In Search of the Cholesterol Gene Products for Science Education

This experiment includes reagents for the colorimetric enzymatic reaction which is the basis of the clinical cholesterol test. In addition, using agarose gel electrophoresis, students will analyze a simulated genetic screening for a disease.

Manufacturer:  Edvotek™ 316

Catalog No. S66830


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Includes: instructions, cholesterol standard solution, standard DNA markers, control samples, simulated patient serum samples and DNA samples, cholesterol oxidase enzyme, potassium iodide, color enhancer & color developer, agarose, electrophoresis buffer, InstaStain™ Ethidium Bromide

Requires :
  • Horizontal gel electrophoresis apparatus
  • Hotplate, micropipets, balance, waterbath, and spectrophotometer
  • 250mL Flasks
  • UV transilluminator
  • All necessary safety equipment
  • Distilled or deionized water


Description

Description

Coronary heart disease and stroke are major causes of death in the Western world. Elevated blood cholesterol levels are a serious risk factor for both conditions. The genetic disease familial hypercholesterolemia (FH) causes an increase in blood levels of the 'bad' form of cholesterol, low-density lipoprotein (LDL). In untreated patients with the mutant FH gene, the condition can cause premature death. This experiment includes reagents for the colorimetric enzymatic reaction which is the basis of the clinical cholesterol test. In addition, using agarose gel electrophoresis, students will analyze a simulated genetic screening for a disease.
Specifications

Specifications

10 Lab Groups
Instructions, cholesterol standard solution, standard DNA markers, control samples, simulated patient serum samples and DNA samples, cholesterol oxidase enzyme, potassium iodide, color enhancer and color developer, agarose, electrophoresis buffer, InstaStain™ ethidium bromide
Some components require freezer and refrigerator storage
Agarose gel electrophoresis
Horizontal gel electrophoresis apparatus, power supply, automatic micropipette with tips, balance, microwave oven or hot plate, incubation oven or water bath, spectrophotometer and cuvettes, UV transilluminator, pipet pumps or bulbs, lab glassware, large weigh boats
Complete in 2 hours 15 minutes
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