Tocris™ Indibulin

Microtubule destabilizer

Manufacturer: Tocris™ 3728/50

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Catalog No. 37-285-0R

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Disclaimers:

For Research Use Only


    Specifications

    Product Type Indibulin
    Inhibitors Indibulin
    Purity >98
    Molecular Weight 389.83
    Quantity 50mg

    Microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3µM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285µM). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.

    • Chemical Name: 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
    • Formula: C22H16ClN3O2
    • CAS Number: 204205-90-3
    • Solubility: Soluble to 25mM in DMSO
    • Purity: >98

  • Description & Specifications

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