Thermo Scientific Lab Vision Insulin Receptor (α -Subunit) Ab-1, Mouse Monoclonal Antibody
Ensure accurate, reproducible results in experiments with the Thermo Scientific Insulin Receptor (α-Subunit) Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Thermo Scientific MS631P1
Ensure accurate, reproducible results in experiments with the Thermo Scientific Insulin Receptor (α-Subunit) Ab-1, Mouse Monoclonal Antibody.The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a Β-α-α-Β configuration. The Β-subunit (95kDa) possesses a single transmembrane domain, whereas the α-subunit (135kDa) is completely extracellular.
Host Species: Mouse
Species Reactivity: Human. Weakly with Cow, Pig and Sheep. Does not react with rabbit, mouse and rat. Others not known.
Epitope: aa 469-592 (exon 7/8)
Immunogen: IM-9 lymphocytes followed by purified insulin receptor
Molecular Weight: 135kDa
Positive Control: IM-9 lymphocyte cells, Placenta
Cellular Localization: Membrane Ab-1 inhibits insulin binding and mimics insulin action. It is excellent for immunoprecipitation of alpha-subunit of IR.
- Insulin-like Agonist
- Inhibits (~80%) Insulin Binding (10nM)
- Tyrosine Kinase Assay (Ab-mediated capture on microplates)
USA: RUO; Int'l: RUO
|Insulin Receptor (alpha-Subunit) Ab-1|
|IM-9 lymphocytes followed by purified insulin receptor|
|Steroids Hormones and Growth Factors|
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