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Thermo Scientific™ Lab Vision™ Insulin Receptor (α -Subunit) Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ Insulin Receptor (α-Subunit) Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ MS631PABX

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Catalog No. MS631PABX


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Description

Description

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ Insulin Receptor (α-Subunit) Ab-1, Mouse Monoclonal Antibody.

The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a Β-α-α-Β configuration. The Β-subunit (95kDa) possesses a single transmembrane domain, whereas the α-subunit (135kDa) is completely extracellular.

Host Species: Mouse

Clone: 83-14

Isotype: IgG2a/κ

Species Reactivity: Human. Weakly with Cow, Pig and Sheep. Does not react with rabbit, mouse and rat. Others not known.

Epitope: aa 469-592 (exon 7/8)

Immunogen: IM-9 lymphocytes followed by purified insulin receptor

Molecular Weight: 135kDa

Positive Control: IM-9 lymphocyte cells, Placenta

Cellular Localization: Membrane Ab-1 inhibits insulin binding and mimics insulin action. It is excellent for immunoprecipitation of alpha-subunit of IR.

Recommended for:

  • Immunoprecipitation
  • ELISA
  • Insulin-like Agonist
  • Inhibits (~80%) Insulin Binding (10nM)
  • Tyrosine Kinase Assay (Ab-mediated capture on microplates)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

Insulin Receptor (alpha-Subunit) Ab-1
Monoclonal
1mg/mL
Concentrated
IM-9 lymphocytes followed by purified insulin receptor
200μL
Steroids Hormones and Growth Factors
Primary
Human
Immunoprecipitation
83-14
Unconjugated
Murine
IgG2a kappa
RUO
Primary
Monoclonal
SDS
Documents
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