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Integrin beta 4/CD104 Mouse anti-Human, Alexa Fluor™ 350, Clone: UM-A9, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP234507AF350

Catalog No. NP23407A30


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Description

Description

Integrin beta 4/CD104 Monoclonal antibody specifically detects Integrin beta 4/CD104 in Human samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen).
Specifications

Specifications

Integrin beta 4/CD104
UM-A9
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen
Conjugated, Purified
ITGB4
Human squamous cell carcinoma (UM-SCC1)
Protein A purified
Adaptive Immunity, Immunology, Phospho Specific, Signal Transduction
Primary
3691.0
Human
ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Frozen), Western Blot
Alexa Fluor™ 350
50 mM sodium borate with 0.05% sodium azide
CD104, CD104 antigen, GP150, integrin beta-4, integrin beta-4 subunit, integrin, beta 4
Mouse
IgG2a Kappa
0.1 mL
Store at 4°C in the dark.
Monoclonal
Recognizes a protein of 205kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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