IntegrinalphaL/CD11a Mouse anti-Mouse, Janelia Fluor 549, Clone: 87-6F9, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP142196JF549
DescriptionIntegrinalphaL/CD11aMonoclonalantibody specifically detects IntegrinalphaL/CD11a in Mouse samples.
|Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen|
|The antibody reacts with the CD11a antigen.|
|Protein A or G purified|
|Adaptive Immunity, Cellular Markers, Cytokine Research, Hematopoietic Stem Cell Markers, Immunology, Myeloid Cell Markers, Signal Transduction, Stem Cell Markers|
|Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen)|
|Janelia Fluor 549|
|50mM Sodium Borate with 0.05% Sodium Azide|
|CD11 antigen-like family member A, CD11a antigen, CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide, integrin alpha-L, integrin gene promoter, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide), Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte function-associated molecule 1 alpha chain, LFA-1, LFA-1 alpha, LFA1A, LFA-1A, lymphocyte function-associated antigen 1|
|Store at 4°C in the dark.|
|CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages with increase in levels on memory T cells. CD11a or LFA-1 has a key role in mediating leukocyte adhesion to endothelium during inflammatory responses through binding to ICAM-1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many T cell functions and immune phenomena. Mol. weight in SDS gels is about 180 kD. Part of heterodimer with CD18 (integrin beta-2). A defect in beta-2 expression results in leucocytes adhesion deficiency (LAD) in which patients suffer from recurring bacterial infections. Source: A BALB/c mouse was immunized and SP2/0 cells were used for fusion with splenocytes.|
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