Invitrogen™ IP3 Receptor 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596855

Catalog No. PIPA596855

Description

Positive Samples: HeLa, HT-1080, Mouse kidney, Mouse brain; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein Immunogen sequence: ASNLVIDLIM NASSDRVFHE SILLAIALLE GGNTTIQHSF FCRLTEDKKS EKFFKVFYDR MKVAQQEIKA TVTVNTSDLG NKKKDDEVDR DAPSRKKAKE.

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

Specifications

• Antigen: IP3 Receptor 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Itpr1
• Gene Alias: ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; inositol 1,4,5-trisphosphate-binding protein P400; InsP>3>R type I; Insp3r; InsP3R type I; insP3R1; IP3 receptor; IP3 receptor isoform 1; Ip3r; IP-3-R; IP3R 1; IP3R1; Itpr1; Itpr-1; opisthotonus; opt; P400; Pcd6; Pcp1; Pcp-1; PPP1R94; protein PCD-6; protein phosphatase 1, regulatory subunit 94; Purkinje cell protein 1; SCA15; SCA16; SCA29; SI-SIII-SIIA; Type 1 inositol 1,4,5-trisphosphate receptor; type 1 InsP3 receptor
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16438, 25262, 3708
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunoprecipitation, Western Blot
• Concentration: 1.94 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P11881, P29994, Q14643
• Gene Symbols: Itpr1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1812-1911 of human IP3R (NP_001365381).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG