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Importin 8 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550687

Catalog No. PA550687


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Description

Description

The antibody detects endogenous levels of total IPO8 protein.

Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.
Specifications

Specifications

Importin 8
Polyclonal
Unconjugated
IPO8
Liquid
IPO8
Synthetic peptide corresponding to a region derived from internal residues of human importin 8
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
2.4 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
O15397
RANBP8
Rabbit
IgG
100 μL
-20°C
Primary
10526
Documents
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