IQGAP3 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA589674
Immunogen sequence: QRRVLRNLRR LEALGLVSAR NGYQGLVDEL AKDIRNQHRH RHRRKAELVK LQATLQGLST KTTFYEEQGD YYSQYIRACL DHLAPDSKSS GKGKKQPSLH YTAAQLLEKG VLVEIEDLPA SHFRNVIFDI TPGDEAGKFE VNAKFLGVDM ERFQLHYQDL LQLQYEGVAV MKLFNKAKVN VNLLIFLLNK KFLRK; Positive Samples: 293TIQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson′s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, maligt melanoma and multiple myeloma.
|Recombit fusion protein containing a sequence corresponding to amino acids 1437-1631 of human IQGAP3|
|Human, Mouse, Rat|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Antigen Affinity Chromatography|
|128239, 310621, 404710|
|-20° C, Avoid Freeze/Thaw Cycles|
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