IQGAP3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA589674

Catalog No. PIPA589674

Description

Immunogen sequence: QRRVLRNLRR LEALGLVSAR NGYQGLVDEL AKDIRNQHRH RHRRKAELVK LQATLQGLST KTTFYEEQGD YYSQYIRACL DHLAPDSKSS GKGKKQPSLH YTAAQLLEKG VLVEIEDLPA SHFRNVIFDI TPGDEAGKFE VNAKFLGVDM ERFQLHYQDL LQLQYEGVAV MKLFNKAKVN VNLLIFLLNK KFLRK; Positive Samples: 293T

IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson′s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, maligt melanoma and multiple myeloma.

Specifications

• Antigen: IQGAP3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IQGAP3
• Gene Symbols: Iqgap3
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 1437-1631 of human IQGAP3
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 1.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q86VI3
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 128239, 310621, 404710
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid