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Human IRAK1, Synthetic Peptide, Invitrogen™

Synthetic Peptide

Manufacturer:  Invitrogen PEP0001

Catalog No. PEP0001


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Description

Description

IRAK Synthetic Peptide, PEP-0001, from Invitrogen.

Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK ft.s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state. This peptide corresponds to 13 amino acids near the carboxy terminus of human IRAK.PEP-0001 can be used as a blocking peptide with polyclonal antibody PA5-19855.
Specifications

Specifications

Synthetic Peptide
purified
50μg
Blocking Assay, Control
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
Human
RUO
0.02% sodium azide
IRAK1
Blocking Assay, Control
3654
Human
200μg/mL
Liquid
N
PBS
-20°C
Human IRAK1
P51617
Peptide
Documents
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