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Human IRAK2, Synthetic Peptide, Invitrogen™

Synthetic Peptide

Manufacturer:  Invitrogen PEP0062

Catalog No. PEP0062


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Description

Description

IRAK2 Synthetic Peptide, PEP-0062, from Invitrogen.

IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B , which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues. This peptide corresponds to 20 amino acids near the carboxy terminus of human IRAK2.PEP-0062 can be used as a blocking peptide with polyclonal antibody PA5-19937.
Specifications

Specifications

Synthetic Peptide
purified
50μg
Blocking Assay, Control
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
Human
RUO
0.02% sodium azide
IRAK2
Blocking Assay, Control
3656
Human
200μg/mL
Liquid
N
PBS
-20°C
Human IRAK2
O43187
Peptide
Documents
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