Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

IRAK2 Mouse anti-Human, Clone: OTI4C1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526613

Catalog No. PIMA526613


Add to cart

Description

Description

IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B , which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation. IRAKs also associate with Toll-like receptor (TLR) and the domit negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.
Specifications

Specifications

IRAK2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O43187
6330415L08Rik, AI649099, IRAK-2; interleukin-1 receptor-associated kinase 2c; interleukin-1 receptor-associated kinase-like 2; mu-IRAK-2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3656
Immunohistochemistry (Paraffin), Western Blot
OTI4C1
Unconjugated
IRAK2
Liquid
IRAK2
Human recombit protein fragment corresponding to amino acids 362-625 of IRAK2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit