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IRAK4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 182211AP

Catalog No. 50-173-2055


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Description

Description

Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappa-B and MAP kinase (MAPK) by IL-1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
Specifications

Specifications

IRAK4
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8R4K2, Q9NWZ3
IPD1, IRAK 4, IRAK4, NY REN 64, REN64
Rabbit
IgG
150 μL
-20°C
Primary
266632, 300177, 51135
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
IRAK4
Liquid
IRAK4
IRAK4 Fusion Protein Ag12982
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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