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IRF7 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 223921AP

Catalog No. 50-173-3855


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Description

Description

This antibody is a rabbit polyclonal antibody raised against the C-terminal 349 amino acid residues of human IRF7 D. The molecular weight of non-phosphorylated IRF7 is 44 kDa while phosphorylated IRF7 is 80-90 kDa.

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
Specifications

Specifications

IRF7
0.35 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q92985
interferon regulatory factor 7, IRF 7, IRF 7H, IRF7, IRF7A
Rabbit
IgG
150 μL
-20°C
Primary
3665
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
IRF7
Liquid
IRF7
IRF7 Fusion Protein Ag18059
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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