IRF7 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 223921AP
This antibody is a rabbit polyclonal antibody raised against the C-terminal 349 amino acid residues of human IRF7 D. The molecular weight of non-phosphorylated IRF7 is 44 kDa while phosphorylated IRF7 is 80-90 kDa.Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|interferon regulatory factor 7, IRF 7, IRF 7H, IRF7, IRF7A|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|IRF7 Fusion Protein Ag18059|
|Antigen Affinity Chromatography|
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