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IRF8 Mouse anti-Human, Mouse, eFluor 450, Clone: V3GYWCH, eBioscience
Mouse Monoclonal Antibody
Manufacturer: eBioscience 48985282
Description
The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50 kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the d
eFluor 450 emits at 446 nm and is excited with the violet laser line (405 nm). Please make sure that your instrument is capable of detecting this fluorochrome. Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.Specifications
IRF8 | |
Monoclonal | |
0.2 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
P23611, Q02556 | |
Irf8 | |
IgG1, kappa | |
100 μg | |
4° C, store in dark, DO NOT FREEZE! | |
Primary | |
15900, 3394 |
Flow Cytometry | |
V3GYWCH | |
eFluor™ 450 | |
IRF8 | |
Liquid | |
Mouse | |
Affinity Chromatography | |
RUO | |
Antibody | |
Monoclonal | |
Human, Mouse |
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