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IRF8 Mouse anti-Human, Mouse, eFluor™ 450, Clone: V3GYWCH, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  eBioscience 48985282

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Catalog No. 48-985-282


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Description

Description

The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50 kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the d

eFluor 450 emits at 446 nm and is excited with the violet laser line (405 nm). Please make sure that your instrument is capable of detecting this fluorochrome. Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
Specifications

Specifications

IRF8
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P23611, Q02556
Irf8
IgG1, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
15900, 3394
Flow Cytometry
V3GYWCH
eFluor™ 450
IRF8
Liquid
Mouse
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Mouse
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