IRF8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 189771AP
DescriptionIRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|H ICSBP, ICSBP, ICSBP1, interferon regulatory factor 8, IRF 8, IRF8|
|15900, 292060, 3394|
|Immunohistochemistry (Paraffin), Western Blot|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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