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IRF8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 189771AP

Catalog No. 50-173-2300


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Description

Description

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
Specifications

Specifications

IRF8
1.11 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P23611, Q02556
H ICSBP, ICSBP, ICSBP1, interferon regulatory factor 8, IRF 8, IRF8
Rabbit
IgG
150 μL
-20°C
Primary
15900, 292060, 3394
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
IRF8
Liquid
IRF8
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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