Tocris™ Ispinesib

High affinity and selective allosteric KSP inhibitor

Manufacturer: Tocris™ 5408/50

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Catalog No. 54-085-0

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For Research Use Only


    Description Ispinesib
    Quantity 50mg
    Product Type Ispinesib
    Molecular Weight 517.06
    Purity >98

    High affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app = 1.7nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro. Induces tumor regression of breast cancer cell xenografts in mice.

    • Chemical Name: N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide
    • Formula: C30H33ClN4O2
    • CAS Number: 336113-53-2
    • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
    • Purity: >98

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